Apixaban (I) in several aqueous co-solvent mixtures: Solubility, solvent effect and preferential solvation
H Li, A Farajtabar, Y Xie, Z Li, H Zhao - The Journal of Chemical …, 2020 - Elsevier
… apixaban solubility and thermodynamic features of apixaban … of equilibrated solids, signifying
that apixaban presents in … the drug apixaban used in this contribution belongs to form I. …
that apixaban presents in … the drug apixaban used in this contribution belongs to form I. …
Cocrystals of apixaban with improved solubility and permeability: formulation, physicochemical characterization, pharmacokinetic evaluation, and computational …
JR Madan, SV Waghmare, RB Patil… - Assay and drug …, 2021 - liebertpub.com
… Physical properties of crystalline form depend on the … to form salts. Thus, this method is not
limited to only ionizable APIs. Overall, cocrystallization process leads to the self-assembly of …
limited to only ionizable APIs. Overall, cocrystallization process leads to the self-assembly of …
Dissolution behavior and thermodynamic properties of apixaban in pure and mixed solvents
C Du, Y Cong, Y Zhang, Y Xue, B Qiao, T Ye… - The Journal of Chemical …, 2020 - Elsevier
… The solubility profile of apixaban in pure and mixed solvents within the temperature range
from (… The solid state of apixaban in equilibrated form was characterized using powder X-ray …
from (… The solid state of apixaban in equilibrated form was characterized using powder X-ray …
Des-igning the future of drug delivery: A journey from fundamentals to drug delivery applications
… behavior reminiscent of a sliding puzzle, where their mobility … their pure solid forms, but lower
than that of their liquid forms. … It also balances fitting data without overfitting by building the …
than that of their liquid forms. … It also balances fitting data without overfitting by building the …
An extension of biorelevant fed-state dissolution tests to clinical pharmacokinetics–A study on gastrointestinal factors influencing rivaroxaban exposure and efficacy in …
M Romański, J Giebułtowicz, E Gniazdowska… - International Journal of …, 2024 - Elsevier
… An important piece of the puzzle is the limited dissolution of … function for the curve fitting,
both from scipy (v. 1.7.1) library. … first-order transit of solid and dissolved drug forms with a rate …
both from scipy (v. 1.7.1) library. … first-order transit of solid and dissolved drug forms with a rate …
Glycan Mapping of Low-Molecular-Weight Heparin Using Mass Spectral Correction Based on Chromatography Fitting with “Glycomapping” Software
N Yan, F Song, Y Ouyang, D Li, H Tian, L Yi… - Analytical …, 2022 - ACS Publications
… The characteristics of the three types of chromatographic peaks and their first and … fitting.
The part 4 from the right is taken as an example to demonstrate the logic of the iterative fitting for …
The part 4 from the right is taken as an example to demonstrate the logic of the iterative fitting for …
Versatile Nanoparticulate Systems as a Prosperous Platform for Targeted Nose–Brain Drug Delivery
… Cubosomes are nanoparticles formed from certain surfactants or polar lipids that self-assemble
in water to a honeycombed like liquid crystalline particles. (126) Cubosomes have high …
in water to a honeycombed like liquid crystalline particles. (126) Cubosomes have high …
Repurposing approved drugs for cancer therapy
CH Schein - British Medical Bulletin, 2021 - academic.oup.com
… as an adjunct therapy for different types of cancers, some of … to control clotting, such as
apixaban (Eliquis), a factor Xa … compounds is the need to assemble a proper patient pool for a …
apixaban (Eliquis), a factor Xa … compounds is the need to assemble a proper patient pool for a …
[图书][B] Structural biology in drug discovery: methods, techniques, and practices
JP Renaud - 2020 - books.google.com
… No part of this publication may be reproduced, stored in a retrieval system, or transmitted,
in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, …
in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, …
Round-up of English patent litigation in 2022
T Cook - Journal of Intellectual Property Law and Practice, 2023 - academic.oup.com
… , with which certain types of insufficiency can correspond. In … and has no application to ‘puzzles
at the edge of the claim’. … ’ arguments about how press-fitting works were not allowed …
at the edge of the claim’. … ’ arguments about how press-fitting works were not allowed …